You look in the mirror and those crow’s feet around your eyes seem deeper than they were last month. The “11” lines between your eyebrows have become permanent fixtures. Maybe you’ve thought about Botox, but the cost adds up fast when you need injections every three months. Or maybe needles just aren’t your thing.
Here’s the good news: there are Best Liquid Botox Face Cream for Wrinkles and Crow’s Feet options that actually deliver visible results. I’ve spent years testing peptide serums and wrinkle treatments with clients in their 50s, 60s, and beyond. Some products were complete wastes of money. But several genuinely work to smooth expression lines, reduce crow’s feet, and firm aging skin. I’m going to share exactly which ones are worth your hard-earned dollars.
Be sure to see my latest beauty product review, 31 Must-Have Beauty Products Every Woman Should Have!
Quick Picks: Best Liquid Botox Creams at a Glance
| Best For | Product | Price Range | Key Benefit |
|---|---|---|---|
| Budget Pick | The Ordinary Argireline Solution 10% | 10-15 | Highest concentration argireline for the price |
| Best Overall Value | The Ordinary Matrixyl 10% + HA | 15-20 | Builds collagen while hydrating |
| Immediate Results | Peter Thomas Roth Instant FIRMx | 28-38 | Visible tightening in 5-10 minutes |
| Deep Wrinkles | Murad Targeted Wrinkle Corrector | 55-85 | Instant filler effect for stubborn lines |
| Professional Grade | SkinCeuticals P-Tiox | 19-29 | Clinical results, reduces 9 expression line types |
| Best Eye Cream | The Ordinary Multi-Peptide Eye Serum | 15-18 | Complete eye area treatment |
Can’t decide? Start with The Ordinary Argireline + Matrixyl combo for under $30 total.
What Is Liquid Botox and How Does It Work?
See product featured in this video
Before we dive into the products, let’s clear something up. There’s no actual Botox in these creams. What you’re getting are powerful peptides and ingredients that work similarly to Botox by:
- Relaxing facial muscles to reduce expression lines
- Boosting collagen production to plump and firm skin
- Hydrating deeply to fill in fine lines from the inside out
- Improving skin elasticity to prevent future wrinkles
The star ingredients are peptides like argireline (acetyl hexapeptide-8) and matrixyl, which clinical studies show can reduce wrinkle depth by up to 48% with consistent use. That’s not as dramatic as Botox injections, but it’s significant improvement without needles, downtime, or the frozen look some women worry about.
Check with your doctor before starting any new skincare routine, especially if you have existing skin conditions or allergies.
The 11 Best Liquid Botox Face Creams That Actually Work
After testing dozens of products on myself and with clients over 50, these are the ones that delivered visible results. I’ve organized them from most affordable to premium options so you can find something that fits your budget.
1. The Ordinary Argireline Solution 10%
What It Is: This lightweight serum contains 10% argireline, one of the highest concentrations you’ll find in an over-the-counter product. It’s water-based, absorbs quickly, and costs less than your monthly coffee budget.
Why People Love It: My client Leah, 58, calls it her “emergency wrinkle eraser.” She applies it to her crow’s feet and forehead lines every morning, and within two weeks, she noticed her expression lines looked softer. The clinical data backs her up. A 2013 study showed argireline reduced crow’s feet by 48% after 30 days of twice-daily use.
Women love that it’s:
- Budget-friendly at around $10-15
- No-fuss application with a dropper bottle
- Gentle enough for sensitive skin
- Fast-absorbing so it layers well under makeup
The catch? It works best on fine to moderate lines. If you have deep, set-in wrinkles, you’ll want to pair this with something stronger (keep reading).
Pro tip: Apply it to damp skin right after cleansing. The moisture helps the peptides penetrate deeper.
Shop The Ordinary Argireline Solution on Amazon
2. The Ordinary Matrixyl 10% + HA
What It Is: This serum combines matrixyl 3000 (a collagen-boosting peptide complex) with hyaluronic acid for deep hydration. It’s designed to improve wrinkle depth and skin firmness over time.
Why People Love It: Think of this as the construction crew for your face. While argireline relaxes muscles, matrixyl rebuilds the foundation. Clinical studies show it can reduce wrinkle depth by 23.3% over two months and improve skin firmness by stimulating collagen production up to 350%.
I use this one every night before bed, and after eight weeks, I noticed my skin felt bouncier and looked plumper. A client in her mid-60s told me her daughter asked if she’d “done something” to her face. That’s the goal, right? Looking refreshed, not different.
Women appreciate:
- Dual action (immediate hydration + long-term firming)
- Affordable price point (around $15-20)
- Works on face and neck
- Visible results within 6-8 weeks
Best for: Women who want to prevent future wrinkles while treating existing ones.
Shop The Ordinary Matrixyl 10% + HA on Amazon
3. The Ordinary Multi-Peptide Eye Serum
What It Is: This targeted eye serum packs multiple peptide technologies into one bottle, specifically formulated for the delicate eye area. It addresses crow’s feet, under-eye wrinkles, puffiness, and dark circles all at once.
Why People Love It: My eyes are my problem area. I squint when I’m concentrating (which is constantly when I’m training clients), and by age 50, the damage was undeniable. This serum became my holy grail for the eye area.
What makes it special:
- Combines argireline and matrixyl for dual wrinkle-fighting power
- Includes Eyeliss peptides to reduce puffiness
- Caffeine brightens dark circles
- Ridiculously affordable at $15-18
After four weeks of twice-daily use, my crow’s feet looked noticeably smoother. A bonus? It doesn’t sting or irritate even though the eye area is sensitive.
Application tip: Use your ring finger to pat (never rub) around the orbital bone. That’s the bony area around your eye socket, staying away from the immediate lash line.
Shop The Ordinary Multi-Peptide Eye Serum on Amazon
4. Neutrogena Rapid Wrinkle Repair Retinol Eye Cream
What It Is: This drugstore hero combines retinol with hyaluronic acid in a formula specifically designed for the eye area. It targets crow’s feet, fine lines, and dark circles with proven anti-aging ingredients.
Why People Love It: Retinol is the gold standard for wrinkle reduction, backed by decades of research. But it can be harsh, especially around the eyes. Neutrogena figured out how to make it gentle enough for daily use while still delivering results.
My 54-year-old client Jennifer swears by this. She’d tried expensive eye creams that irritated her skin, but this one? No redness, no flaking, just smoother skin. After 12 weeks, clinical testing shows it visibly reduces crow’s feet and dark circles.
Why it works:
- Retinol accelerates cell turnover to reveal fresh skin
- Hyaluronic acid provides plumping hydration
- Affordable at $18-25
- Available at drugstores (no waiting for shipping)
Important: Always use SPF during the day when using retinol products. Retinol increases sun sensitivity.
Shop Neutrogena Rapid Wrinkle Repair Eye Cream on Amazon
5. Peter Thomas Roth Instant FIRMx Temporary Eye Tightener
What It Is: This is the product that went viral on TikTok for making under-eye bags disappear in minutes. It uses skin-tightening silicates (Firm-A-Tite technology) plus peptides to create an instant lifting effect that lasts all day.
Why People Love It: Full disclosure: This sits more in the makeup category than skincare. Think of it as shapewear for your eye area. It creates an immediate tightening film on the skin that smooths crow’s feet and lifts droopy under-eyes within 5-10 minutes.
I use this for special occasions or mornings after poor sleep. One client uses it daily under her concealer and says it’s changed her makeup routine completely. The before-and-after results can be dramatic, especially if you have puffiness or loose skin.
The trade-offs:
- Instant results but temporary (washes off)
- Long-term benefits from peptides with continued use
- Tricky application (requires clean, completely dry skin)
- Can leave white residue if you use too much
Application trick: Less is more. Start with a tiny amount (size of a rice grain) and let it dry for 7-10 minutes without making facial expressions. You can add more if needed, but only while the first layer is still wet.
Shop Peter Thomas Roth Instant FIRMx on Amazon
6. Murad Targeted Wrinkle Corrector
What It Is: This concentrated treatment acts like an instant filler, flooding deep wrinkles with bioavailable hyaluronic acid while hexapeptide boosts elasticity. It comes with a metal applicator tip for precise application.
Why People Love It: I call this my “wrinkle emergency kit.” It’s specifically designed for those stubborn, deep-set lines – the ones between your eyebrows, forehead creases, crow’s feet, and lines around your mouth.
What sets it apart:
- Works like instant filler by flooding wrinkles with hydration
- Hexapeptide helps skin bounce back from expression lines
- Squalane prevents moisture loss to resist future wrinkles
- Clinical results: 90% showed improvement in forehead wrinkles, 100% in glabella lines (the “11s”)
The application method matters here. You tap it into the wrinkle with the metal tip – don’t rub. Let it dry completely before applying other products. My client Maria, 61, uses it morning and night on her forehead lines and says people keep asking if she’s using Botox.
Price point: $55-85 (worth it for concentrated treatment on specific problem areas)
Shop Murad Targeted Wrinkle Corrector on Amazon
7. SkinCeuticals P-Tiox Anti-Wrinkle Serum
What It Is: This is the premium peptide serum inspired by neurotoxin injections. It’s clinically proven to reduce nine types of expression lines and reveal “glass skin” radiance in just one week.
Why People Love It: When my client asked me to find the best of the best, regardless of price, this is what I recommended. It’s formulated with an advanced peptide complex (hexapeptide + dipeptide) amplified by polyhydroxy acid (gentle exfoliant), niacinamide, and laminaria extract.
The clinical data is impressive:
- Reduces 9 types of contraction lines – even ones Botox doesn’t traditionally treat
- Reveals glass skin radiance in 1 week
- Physician-tested to complement neurotoxin injections
- Suitable for all skin types, including sensitive
My 57-year-old client Lisa invested in this after years of Botox and loves that it maintains her results between appointments. She applies it twice daily and says her skin looks smoother and has that coveted lit-from-within glow.
The investment: $19 for 1 oz (this is budget territory, and it lasts 3-4 months with twice-daily use)
Worth it if: You want clinical-grade results and can invest in your skincare routine.
Shop SkinCeuticals P-Tiox on Amazon
8. Medik8 Crystal Retinal Ceramide Eye
What It Is: This eye cream combines retinaldehyde (a more potent, faster-acting form of retinol) with ceramides to address crow’s feet while hydrating and strengthening the delicate eye area.
Why People Love It: Retinaldehyde converts to retinoic acid (the active form your skin actually uses) faster than regular retinol, which means you see results sooner with less irritation. The ceramides are the secret weapon here, protecting your skin barrier so you can use this powerful ingredient without the typical dryness and flaking.
Benefits:
- Works faster than standard retinol
- Ceramides prevent irritation
- Targets crow’s feet specifically
- Visible improvement in 4-6 weeks
I recommend this for women who’ve tried retinol products before and want to level up. Start using it 2-3 times per week, then gradually increase to nightly as your skin adjusts.
Shop Medik8 Crystal Retinal Ceramide Eye on Amazon
9. ISDIN Melatonik Serum
What It Is: This nighttime treatment contains melatonin (yes, the sleep hormone!) plus bakuchiol (a plant-based retinol alternative) and vitamin C. It’s designed to work while you sleep, improving wrinkles and texture without irritation.
Why People Love It: If your skin is too sensitive for retinol, this is your answer. Bakuchiol delivers similar benefits (increased collagen, reduced wrinkles, improved texture) without the redness and peeling. Plus, melatonin acts as a powerful antioxidant that neutralizes damage from daily stress and pollution.
My client with rosacea couldn’t tolerate any active ingredients until she tried this. After eight weeks, her skin looked noticeably smoother and more even-toned.
Perfect for:
- Sensitive skin that can’t handle retinol
- Nighttime repair while you sleep
- Combining with morning peptide serums
- Improving overall texture and tone
Shop ISDIN Melatonik Serum on Amazon
10. No7 Anti-Aging Eye Cream
What It Is: Good Housekeeping Lab tested this budget-friendly eye cream and found it significantly improves crow’s feet and firmness around the eyes. It’s clinically proven to reduce the appearance of wrinkles in just four weeks.
Why People Love It: Sometimes the best products aren’t the most expensive ones. No7 has been a trusted drugstore brand for decades, and their eye cream delivers pro-retinol benefits at a fraction of designer prices.
What makes it special:
- Clinically proven results within 4 weeks
- Budget-friendly at $15-20
- Available at drugstores (no waiting)
- Gentle enough for twice-daily use
Multiple clients tell me this is their ride-or-die eye cream. It doesn’t sting, absorbs quickly, and works beautifully under makeup. After four weeks, you’ll see smoother skin and reduced crow’s feet.
Shop No7 Anti-Aging Eye Cream on Amazon
11. Alastin Restorative Eye Treatment
What It Is: This dermatologist-recommended peptide eye treatment is specifically cited as a “Botox in a bottle” option for crow’s feet. It features TriHex Technology, which helps clear out damaged collagen and elastin while supporting new, healthy production.
Why People Love It: Dermatologists love this brand because it actually works. The peptide technology helps remove dead collagen fragments (think of it like taking out the trash) while building new, healthy collagen. It’s particularly effective for mature skin that needs serious intervention.
Why it’s worth the investment:
- Dermatologist-recommended
- TriHex Technology clears damaged proteins
- Peptides stimulate new collagen
- Visible improvement in elasticity and firmness
My client Angela, 59, uses this religiously and her dermatologist actually commented on how much younger her eye area looks. She’s been using it for six months and says the crow’s feet that bothered her for years are dramatically improved.
Investment level: $110-130 (professional-grade treatment)
Shop Alastin Restorative Eye Treatment on Amazon
How to Choose the Right Liquid Botox Cream for Your Skin
Not sure which product is right for you? Here’s how I guide my clients:
If you’re on a budget: Start with The Ordinary Argireline Solution and Matrixyl 10% + HA. Use argireline on expression lines (forehead, crow’s feet) in the morning, and matrixyl on your entire face at night. Total investment: under $30. Pair with a quality sunscreen for everyday use to protect your results.
If you want fast results: Peter Thomas Roth Instant FIRMx gives you immediate visible tightening for special occasions, while continuing to improve skin over time with peptides. Perfect for special events and summer weddings.
If you have sensitive skin: ISDIN Melatonik or Medik8 Crystal Retinal Ceramide Eye deliver results without irritation. The ceramides and gentler actives work with your skin, not against it. Learn more about proper skincare for sensitive skin.
If you want professional-grade: SkinCeuticals P-Tiox or Alastin Restorative Eye Treatment are investments, but they deliver clinical-level results at home.
If you’re targeting deep wrinkles: Murad Targeted Wrinkle Corrector is specifically designed for stubborn, etched-in lines that need concentrated treatment.
My Honest Take on What Actually Works
Here’s what I’ve learned after years of testing these products on myself and with dozens of clients over 50:
No cream will give you Botox results. Let’s be realistic. These products can reduce wrinkles by 20-50% with consistent use. Botox can reduce them by 80-90%. But here’s the thing: you can use these creams every day without needles, appointments, or the frozen look some injections create.
Consistency is everything. I see the best results when women commit to twice-daily application for at least 8-12 weeks. Your skin didn’t develop wrinkles overnight, and it won’t erase them overnight either. Just like starting a fitness program, consistency beats intensity.
Combine strategies for best results. I layer my products: argireline in the morning on expression lines, matrixyl at night for collagen building, and a retinol eye cream 3-4 times per week. Plus sunscreen every single day (non-negotiable).
Peptide serums work differently than retinol. Peptides relax muscles and boost collagen. Retinol increases cell turnover. Using both gives you a comprehensive approach to fighting wrinkles, similar to how combining cardio and strength training delivers better fitness results than either alone.
The Products I Keep in My Own Medicine Cabinet
Want to know what’s actually in my bathroom? Here’s my personal routine at 59:
Morning:
- The Ordinary Argireline Solution on forehead and crow’s feet
- SkinCeuticals P-Tiox
- The Ordinary Multi-Peptide Eye Serum
- Sunscreen (always!)
Evening:
- The Ordinary Matrixyl 10% + HA all over face and neck
- Neutrogena Rapid Wrinkle Repair Eye Cream (3-4x per week)
- Night moisturizer
Special Occasions:
- Peter Thomas Roth Instant FIRMx when I need to look extra sharp
Total monthly investment: About $50-80 if I’m using the budget options, closer to $200 if I’m using premium products. Compare that to Botox at $300-600 every 3-4 months, and you can see why so many women are switching to topical options.
Real Talk: When These Creams Aren’t Enough
Sometimes, no amount of cream will give you the results you want. Here’s when you might want to consider professional treatments:
- Very deep wrinkles that are etched into your skin even at rest
- Significant skin laxity with drooping or sagging
- Looking for dramatic change rather than gradual improvement
I’ve had Botox twice – once for my “11” lines and once for crow’s feet. It worked beautifully, but I didn’t love the cost or commitment. Now I maintain results with peptide serums and save professional treatments for special occasions.
The right answer is whatever makes you feel confident and comfortable in your skin.
Your Questions Answered
Q: How long until I see results? Immediate hydration and slight plumping can happen within days. Visible wrinkle reduction typically takes 4-8 weeks. Maximum results appear around 12 weeks of consistent use.
Q: Can I use these products with Botox? Absolutely! Many products (like SkinCeuticals P-Tiox) are designed to complement Botox injections and extend results between appointments.
Q: Will these products work on deep wrinkles? They work best on fine to moderate lines. Very deep, etched-in wrinkles will show improvement but may not disappear completely without professional treatment.
Q: Are there side effects? Most peptide serums are well-tolerated. Retinol products can cause initial dryness or flaking. Always patch test new products and introduce them gradually.
Q: Do I need to use them forever? If you stop using them, your wrinkles will gradually return to their baseline. Think of it like going to the gym – the results last as long as you maintain the routine.
The Bottom Line
After testing dozens of “liquid Botox” products, here’s my honest conclusion: The right combination of peptide serums, retinol, and hydration can significantly reduce wrinkles and improve skin texture. Will they replace Botox? Probably not for everyone. But they offer a needle-free, budget-friendly alternative that delivers real, visible results when used consistently.
My top recommendations:
- Best budget option: The Ordinary Argireline Solution + Matrixyl 10% + HA
- Best immediate results: Peter Thomas Roth Instant FIRMx
- Best professional-grade: SkinCeuticals P-Tiox
- Best for deep wrinkles: Murad Targeted Wrinkle Corrector
- Best overall eye cream: The Ordinary Multi-Peptide Eye Serum
Remember, aging is a natural part of life, and your crow’s feet tell the story of your laughter, joy, and years of smiling. Whether you choose to embrace them or minimize them is entirely your decision. What matters is feeling confident and comfortable in your own skin.
If you decide to try these products, give them at least 8-12 weeks of consistent use. Take before photos so you can track your progress. And remember to always wear sunscreen – it’s the single best anti-aging product you can use.
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- Best Anti-Aging Skin Care Products for 60s
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About the author
Claudia Faucher is a full-time fitness training expert and lifestyle blogger. She is also been a certified Les Mills BodyPump instructor for the past 5 years and a fitness instructor for over 20 years. Claudia is a personal trainer and creates fitness training programs for seniors and people of all ages. She likes to use her skills and experiences to help others on their fitness journeys.
Last update on 2026-01-06 / Affiliate links / Images from Amazon Product Advertising API